In 2023, The California Institute of Regenerative Medication (CIRM) used ACCO’s toolkits and social media frames for ACCO’s #GoGold campaign to unfold consciousness of childhood most cancers and analysis that’s being performed at their facility. Their investments are over $20 million for childhood most cancers mind tumor analysis at Stanford and Metropolis of Hope. As ACCO reached out to debate CIRM’s #GoGold marketing campaign, we wished them to spotlight their childhood most cancers mind tumor analysis. Right here is their article.
Leo David Wang, MD, PhD (left) | Photograph: Courtesy Metropolis of Hope
Most cancers stays the primary reason behind dying by illness for kids in America. Each three minutes a toddler is identified with most cancers worldwide and roughly 40,000 youngsters are receiving most cancers remedy at any given time.
Childhood most cancers survivors usually expertise many unwanted effects together with secondary cancers, coronary heart injury, infertility, continual hepatitis, and extra.
The California Institute for Regenerative Medicine (CIRM) is dedicated to proceed funding revolutionary stem cell and gene remedy analysis for childhood most cancers to supply extra remedy choices to youngsters affected by the illness.
In regards to the California Institute for Regenerative Medication (CIRM)
CIRM was based in 2004 when 59% of California voters authorized Proposition 71: the California Stem Cell Research and Cures Initiative. That initiative offered CIRM with $3 billion to fund stem cell analysis within the state.
In 2020, California voters authorized to proceed funding CIRM by the passage of Proposition 14: The California Stem Cell Research, Treatments, and Cures Initiative of 2020. That vote of confidence offered CIRM with a further $5.5 billion to proceed funding regenerative medication analysis and packages within the state.
Since its founding in 2004, CIRM has performed a pivotal function in rising the scientific subject, creating jobs throughout California, and fostering developments that profit various communities. CIRM is proud to have funded greater than 100 scientific trials with the purpose of accelerating the approval of latest therapies for sufferers.
A few of these scientific trials tackle circumstances affecting youngsters with most cancers.
Scientific Analysis Looking for Therapies for Mind Tumors
CIRM is supporting varied scientific trials to search out remedies for mind tumors, the commonest stable tumor of childhood, with roughly 5,000 new diagnoses per yr in the US.
One scientific trial is supported by an $11.9 million award made to the founding director of the Stanford Middle for Most cancers Cell Remedy, Crystal Mackall, M.D. The trial can be testing a remedy for glioma, a devastating mind tumor that happens primarily in youngsters and younger adults. Glioma tumors are virtually all the time deadly. Till now, radiation remedy has been the principle remedy possibility, nevertheless it solely extends survival by a number of months.
CIRM additionally offered $8.4 million in funding to help a Phase 1 clinical trial led by Leo David Wang, MD, PhD at City of Hope Children’s Cancer Center additionally concentrating on malignant mind tumors in youngsters.
Each groups at Stanford and Metropolis of Hope Kids’s Most cancers Middle will deal with pediatric sufferers with aggressive mind tumors utilizing CAR-T cell remedy.
CAR-T cell remedy modifies a affected person’s personal T cells (immune system cells) with a protein referred to as chimeric antigen receptor cell (CAR). These newly created CAR T cells can be reintroduced again into sufferers the place it’s hoped they are going to determine and destroy the mind tumor cells.
“CAR T cell remedy is often given intravenously, after which the cells journey by the bloodstream to search out the tumor. However the blood-brain barrier separates the blood circulation from the central nervous system — which makes it onerous for CAR T cells to entry the mind,” Wang defined. “On this trial, we introduce the CAR T cells instantly into the ventricles of the mind, which works rather more successfully for mind tumors.”
The CIRM-funded analysis at Stanford and Metropolis of Hope Kids’s Most cancers Middle has the potential to remodel the panorama for deadly pediatric mind tumors and supply remedy choices for kids affected by most cancers.
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Study extra in regards to the California Institute for Regenerative Medication at cirm.ca.gov. To discover CIRM-funded scientific trials, visit this page on its website.
