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David Sinclair’s NMN & Resveratrol Protocol – Dosage & Brand

MindNell by MindNell
2 June 2025
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David Sinclair’s NMN & Resveratrol Protocol – Dosage & Brand
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Dr. David Sinclair is a tenured Professor of Genetics at Harvard College. He’s an knowledgeable and pioneer within the discipline of ageing. He’s additionally the writer of the best-selling e-book Lifespan: Why We Age & Why We Don’t Have To, and is the host of the Lifespan Podcast.

Dr. Sinclair has revealed groundbreaking research concerning the advantages of NMN and resveratrol in the case of anti-aging. David believes that not solely can we prolong our lifespan, however we are able to truly reverse it. He himself dietary supplements with resveratrol and NMN, so let’s check out his protocol.

NMN and resveratrol are the highlights of Dr. Sinclair’s anti-aging routine, which is among the causes he seems so younger at 50. David found the anti-aging advantages of those dietary supplements in his analysis lab at Harvard. So right here is his every day NMN and resveratrol stack.

  • NMN – 1 gram every day within the morning (Buy here)
  • Resveratrol – 1 gram every day within the morning combined with yogurt as a result of taking it with a fats supply will increase its bio-availability (Buy here)

Advantages of NMN

NMN, often known as nicotinamide mononucleotide, is a groundbreaking molecule as a result of it is among the first longevity “substances” to be confirmed by science to increase lifespan. As we age, our DNA turns into broken, and our physique’s capacity to restore that DNA decreases as nicely.

Right here’s the place NMN is the star – it truly maintains our DNA and helps to restore broken DNA. Sirtuins are proteins that preserve the epigenome and are chargeable for repairing DNA injury. When NMN is consumed it’s transformed to NAD+, and Sirtuins can solely perform within the presence of NAD+.

According to this 2014 study: “NAD+ turns into limiting throughout ageing, affecting sirtuins’ actions…NAD+ decline is prone to be attributable to a NAD+ biosynthesis defect and elevated depletion..Supplementing key NAD+ intermediates can restore NAD+ranges and ameliorate age-associated pathophysiologies”

So by supplementing with NMN, we are able to preserve wholesome DNA, preserve the epigenome, and restore DNA injury. Dr. Sinclair has not solely mentioned he believes we are able to stay longer, however we are able to truly REVERSE ageing. David dietary supplements 1 gram of NMN every day in capsule kind together with his every day espresso within the morning. Do NOT purchase NMN off Amazon, as they’re extraordinarily low-quality and have been confirmed to be flukes. Whereas David doesn’t point out his model, we suggest the identical one Andrew Huberman takes, which is Renue by Science (code ‘brainflow’ for 15% off).

RELATED READING: Dr. David Sinclair’s Complete Supplement Stack

Advantages of Resveratrol

You’ve doubtless heard of resveratrol. It’s present in crimson wine, and one of many causes consuming a glass at evening has well being advantages. Resveratrol is in a category of plant micronutrients often called polyphenols. Polyphenols are what crops make to battle illness or survive a drought.

One factor researchers like David have concluded is that irritation is enemy primary in the case of ageing. Resveratrol has each anti-inflammatory and antioxidant properties, defending you from a number of the main causes of loss of life equivalent to most cancers, diabetes, and even Alzheimer’s illness.

Resveratrol protects the physique from free radical cell injury. As well as, resveratrol promotes the exercise of Sirtuins (these proteins we talked about above), in addition to selling NMN.

Dr. Sinclair takes 1 gram of resveratrol within the morning combined in yogurt. By taking resveratrol with a fats supply, it improves its bioavailability. As with NMN, we don’t suggest shopping for resveratrol from Amazon. Do your analysis on a top quality resveratrol supply. We additionally suggest resveratrol in powder form by Renue by Science so you’ll be able to combine it with a fats supply.

RELATED READING: Joe Rogan’s Insane Daily Supplement Stack

The place to Purchase

David has by no means talked about what model he makes use of as a result of he makes use of his lab provide. As talked about above, keep away from Amazon in any respect prices. Try this report beneath that examined 21 manufacturers of NMN on Amazon. Astonishingly, 14 manufacturers have been discovered to include LESS THAN 1% of the NMN they claimed to have.

That’s why we suggest going with Renue by Science. They have been the primary firm to report third-party testing of the purity of its product and have been the primary firm to engineer a sublingual NMN powder – making the product much more bioavailable. You can read more about the company here.



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