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The Science & Treatment of Obsessive Compulsive Disorder (OCD) | Huberman Lab Podcast #78

MindNell by MindNell
9 June 2025
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The Science & Treatment of Obsessive Compulsive Disorder (OCD) | Huberman Lab Podcast #78
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On this episode, I clarify the biology and psychology of obsessive-compulsive dysfunction (OCD)—a prevalent and debilitating situation. I additionally focus on the efficacy and mechanisms behind OCD remedies—each behavioral and pharmacologic in addition to holistic and mixture remedies and new rising remedies, together with directed mind stimulation. I clarify the neural circuitry underlying repetitive “thought-action loops” and why in OCD, the compulsive actions merely make the obsessions even stronger. I evaluation cognitive-behavioral therapies like publicity remedy and SSRIs, holistic approaches, and nutraceuticals, detailing the efficacy of every strategy and what science says about mix and sequence remedies. I describe an typically efficient strategy for treating OCD the place clinicians use cognitive behavioral remedy (CBT) to intentionally carry sufferers into states of excessive nervousness whereas encouraging them to suppress compulsive actions with a view to assist them be taught to beat repetitious thought/motion cycles. This episode ought to curiosity anybody with OCD, anybody who is aware of somebody with OCD or OCPD, and extra typically, these excited by how the mind works to manage ideas and actions, whether or not these ideas are intrusive or not.

Thanks to our sponsors
AG1 (Athletic Greens): https://athleticgreens.com/huberman
Thesis: https://takethesis.com/huberman
Eight Sleep: https://www.eightsleep.com/huberman

Dietary supplements from Momentous
Huberman Collection

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Different platforms: https://hubermanlab.com/observe

Full present notes & hyperlinks to peer-reviewed articles: https://hubermanlab.com/the-science-and-treatment-of-obsessive-compulsive-disorder

Timestamps
00:00:00 Obsessive-Compulsive Dysfunction (OCD)
00:03:01 Momentous Dietary supplements, AG1 (Athletic Greens), Thesis, Eight Sleep
00:08:28 What’s OCD and Obsessive-Compulsive Character Dysfunction?
00:11:18 OCD: Main Incidence & Severity
00:15:10 Classes of OCD
00:21:33 Anxiousness: Linking Obsessions & Compulsions
00:27:33 OCD & Familial Heredity
00:29:10 Organic Mechanisms of OCD, Cortico-Striatal-Thalamic Loops
00:39:36 Cortico-Striatal-Thalamic Loop & OCD
00:46:39 Medical OCD Analysis, Y-BOCS Index
00:51:38 OCD & Concern, Cognitive Behavioral Remedy (CBT) & Publicity Remedy
01:01:56 Distinctive Traits of CBT/Publicity Remedy in OCD Therapy
01:10:18 CBT/Publicity Remedy & Selective Serotonin Reuptake Inhibitors (SSRIs)
01:22:30 Concerns with SSRIs & Prescription Drug Therapies
01:25:17 Serotonin & Cognitive Flexibility, Psilocybin Research
01:31:50 Neuroleptics & Neuromodulators
01:36:09 OCD & Hashish, THC & CBD
01:39:29 Ketamine Therapy
01:41:43 Transcranial Magnetic Stimulation (TMS)
01:46:22 Hashish CBD & Focus
01:47:50 Ideas Are Not Actions
01:51:27 Hormones, Cortisol, DHEA, Testosterone & GABA
02:00:55 Holistic Therapies: Mindfulness Meditation & OCD
02:03:28 Nutraceuticals & Dietary supplements: Myo-Inositol, Glycine
02:09:45 OCD vs. Obsessive Compulsive Character Dysfunction
02:20:53 Superstitions, Compulsions & Obsessions
02:31:00 Zero-Price Assist, YouTube Suggestions, Spotify & Apple Critiques, Sponsors, Momentous Dietary supplements, Instagram, Twitter, Neural Community E-newsletter

The Huberman Lab Podcast is for basic informational functions solely and doesn’t represent the apply of medication, nursing or different skilled well being care companies, together with the giving of medical recommendation, and no physician/affected person relationship is shaped. The usage of data on this podcast or supplies linked from this podcast is on the consumer’s personal threat. The content material of this podcast just isn’t supposed to be an alternative choice to skilled medical recommendation, analysis, or therapy. Customers mustn’t disregard or delay in acquiring medical recommendation for any medical situation they could have and may search the help of their well being care professionals for any such situations.

Title Card Photograph Credit score: Mike Blabac – https://www.blabacphoto.com

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