Current research have proven that radiation-induced pelvic toxicity typically requires urological session. Nonetheless, the 10-year incidence of genitourinary toxicity following intensity-modulated radiotherapy (IMRT) amongst sufferers with localised prostate most cancers stays unclear.
Therefore, we carried out a scientific evaluation and meta-analysis to find out the incidence of late genitourinary toxicity counting on Radiation Remedy Oncology Group (RTOG) and Frequent Terminology Standards for Antagonistic Occasions (CTCAE) grade in addition to the incidence of particular genitourinary toxicity.
We screened 4721 research and 6 research met our inclusion standards. All included research concerned normofractionation, three included a hypofractionation comparator arm and none concerned nodal irradiation.
It was discovered that there are few high-quality research reporting 60-month toxicity charges after IMRT. Conservative estimates of 60-month toxicity charges are excessive and there may be want for longer follow-up and constant toxicity reporting requirements.
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