The Human Tumor Atlas Community seeks to grasp the molecular options of tumors and their microenvironments.
Credit score: Nationwide Most cancers Institute
What
New insights from a number of research present important data on how tumors develop, unfold, and reply to therapies. The ten research from the Human Tumor Atlas Network (HTAN), a Nationwide Institutes of Well being (NIH)-funded Most cancers Moonshot℠ initiative to assemble three-dimensional maps of human tumors, will likely be printed Oct. 31, 2024, throughout a number of Nature journals.
A number of research discover the position of the tumor microenvironment and the immune system in selling the unfold of most cancers and its resistance to remedy. Three research map the trajectory of precancerous colorectal tissues towards most cancers by measuring the contributions of a number of molecular and mobile occasions. A number of new HTAN papers describe the event of revolutionary single-cell expertise and evaluation platforms. An accompanying analysis briefing by W. Kimryn Rathmell, M.D., Ph.D., director of NIH’s Nationwide Most cancers Institute (NCI), and Dinah Singer, Ph.D., NCI deputy director for scientific technique and growth, discusses the historical past, progress, and way forward for HTAN.
Launched in 2018, HTAN constructs three-dimensional maps of human tumors that seize their molecular options and surrounding microenvironments over time. The work is being accomplished by groups of investigators from analysis establishments throughout the nation utilizing quite a lot of applied sciences and computational approaches to check tumors on the single-cell degree. This complete, publicly obtainable useful resource goals to assist researchers higher perceive the event and development of most cancers to tell its prevention and remedy. The primary tumor atlas research from this initiative had been printed in 2020 and 2021.
Who
Shannon Hughes, Ph.D., Division of Most cancers Biology, NCI; Sean Hanlon, Ph.D., Heart for Strategic Scientific Initiatives, NCI; Sudhir Srivastava, Ph.D., M.P.H., Division of Most cancers Prevention, NCI
The Research
The gathering of research is on the market at https://www.nature.com/collections/fihchcjehc.
In regards to the Nationwide Most cancers Institute (NCI): NCI leads the Nationwide Most cancers Program and NIH’s efforts to dramatically cut back the prevalence of most cancers and enhance the lives of most cancers sufferers and their households, by way of analysis into prevention and most cancers biology, the event of latest interventions, and the coaching and mentoring of latest researchers. For extra details about most cancers, please go to the NCI web site at or name NCI’s contact middle, the Most cancers Data Service, at 1-800-4-CANCER (1-800-422-6237).
In regards to the Nationwide Institutes of Well being (NIH): NIH, the nation’s medical analysis company, contains 27 Institutes and Facilities and is a part of the U.S. Division of Well being and Human Providers. NIH is the first federal company conducting and supporting fundamental, scientific, and translational medical analysis, and is investigating the causes, therapies, and cures for each widespread and uncommon ailments. For extra details about NIH and its packages, go to .
